High Dose Vitamin C Therapy
High Dose Vitamin C Therapy
. 2021 Jul;15(4):897-900.
doi: 10.1177/1932296820932186. Epub 2020 Jun 7.
Unintended Consequence of High-Dose Vitamin C Therapy for an Oncology Patient: Evaluation of Ascorbic Acid Interference With Three Hospital-Use Glucose Meters
Affiliations
- PMID: 32506941
- PMCID: PMC8258510
- DOI: 10.1177/1932296820932186
Free PMC article
Unintended Consequence of High-Dose Vitamin C Therapy for an Oncology Patient: Evaluation of Ascorbic Acid Interference With Three Hospital-Use Glucose Meters
Brooke M Katzman et al. J Diabetes Sci Technol. 2021 Jul .
Free PMC article
Abstract
The use of high-dose vitamin C in cancer care has offered promising results for some patients. However, the intravenous (IV) doses used for these patients can reach concentrations that interfere with some strip-based glucose meters. We characterized the impact of vitamin C interference, from standard to the very high doses used for some cancer protocols, using three different hospital-use glucose meters. For two of the three devices tested, increasing concentrations of ascorbic acid caused false elevations in the glucose measurements. The third glucose meter did not provide inaccurate results, regardless of the vitamin C concentration present. Rather, above a certain threshold, the device generated error messages and no results could be obtained.
Keywords: ascorbic acid; glucose meter; interference; vitamin C.
Conflict of interest statement
Figures
Graphs of mean glucose difference vs ascorbic acid concentration for the (a) low, (b) normal, and (c) high glucose concentration pools tested on three meters. Missing points for meter A reflect instrument "errors." When results >AMR were obtained, 601 and 452 mg/dL were used for meter 2 and meter 3, respectively.
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Source: https://pubmed.ncbi.nlm.nih.gov/32506941/
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